| abstract |
The invention relates to a raccoon dog parvovirus enteritis and canine distemper dual inactivated vaccine and a preparation method thereof. The active components of the double inactivated vaccine include raccoon dog parvovirus VP2 protein obtained by transfecting Sf9 cells with recombinant baculovirus RDPV-SN1 strain and inactivated antigen of canine distemper virus; Live vaccines have the risk of virulence returning to strong, and the dual inactivated vaccines used in the market generally have the problem of low immune efficacy after inactivation of raccoon dog parvovirus. Double inactivated vaccine prepared from distemper virus inactivated antigen. The dual vaccine can be used for the prevention of raccoon dog parvovirus enteritis and canine distemper at the same time, and has the advantages of good immunogenicity, high safety, strong controllability, high culture efficiency and automation, and large-scale production. It can achieve the purpose of "one needle and two defenses" and has broad application prospects. |