http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110357926-B
Outgoing Links
Predicate | Object |
---|---|
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F13-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-555 |
filingDate | 2019-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2021-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2021-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-110357926-B |
titleOfInvention | Tropolone and phenanthroline mixed manganese complex and preparation method and application thereof |
abstract | The invention discloses a cycloheptatrienol ketone and phenanthroline mixed manganese complex and a preparation method and application thereof. The preparation method of the complex comprises the following steps: placing tropolone, phenanthroline and divalent manganese salt in an organic solvent, adjusting the pH of the system to 9.3-9.5 after dissolving, reacting the obtained mixed solution under the heating condition, cooling the reactant, and separating out crystals to obtain the compound tropolone/phenanthroline/divalent manganese salt composite material; wherein, the divalent manganese salt is manganese chloride and/or manganese sulfate monohydrate; the organic solvent is acetonitrile or a composition of ethanol and methanol. Applicants' experiments show that the complex has an inhibitory activity on certain cancer cells (such as cervical cancer Hela cell line and gastric cancer MGC80-3 cell line) which is equivalent to that of cisplatin, but has less toxicity on normal cells than cisplatin. |
priorityDate | 2019-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 221.