http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110330524-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0e5d196e5f4dc693aaef0e17f74d4d1d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-091 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-14 |
| filingDate | 2019-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c626f48760de8d2a2820eb1f2e58aa10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_445e82953fa2be5f05744dab5ea059e5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17a01c8252c072d9b8b9146a1c1ed41b |
| publicationDate | 2019-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110330524-A |
| titleOfInvention | 1,2-dipalmitoyl-SN-glycerol-3-phosphoethanolamine and its preparation method |
| abstract | The present invention provides a kind of 1,2-dipalmitoyl-SN-glycerol-3-phosphoethanolamine and its preparation method, wherein the preparation method comprises the following steps: step S1, dipalmitin under the action of tetrahydrofuran and alkali, Nucleophilic substitution reaction occurs with POCl3 , and the reaction product is purified after the reaction is completed to obtain intermediate 1, which is (R)-3-((dichlorophosphoryl)oxy)propane-1, 2-dipalmitic acid; step S2, the intermediate 1 undergoes a nucleophilic substitution reaction with N-Fmoc-ethanolamine under the action of tetrahydrofuran and a base, and the reaction product is purified after the reaction is completed to obtain intermediate 2. Said intermediate 2 is (R)-3-(((2-(fluorenylmethoxycarbonylamino) ethoxy) (hydroxyl) phosphoryl) oxygen) propane-1,2-dipalmitate; Step S3, The intermediate 2 undergoes a nucleophilic substitution reaction under the action of a solvent and a base to obtain the 1,2-dipalmitoyl-SN-glycerol-3-phosphoethanolamine. According to the preparation method of the embodiment of the present invention, the final product has higher purity and less by-products. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113735742-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114853806-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022120689-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112299951-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111087420-A |
| priorityDate | 2019-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 75.