| abstract |
The invention discloses a phenyl thiophene sulfonamide compound, a pharmaceutical composition, a preparation method and application thereof. The compound can effectively and selectively inhibit Bcl-xL, Bcl-2 or Mcl-1, especially Mcl-1 in a key protein Bcl-2 family in the process of apoptosis at a molecular level. Meanwhile, they are used for cancer cells, especially human cervical cancer cells HeLa and human acute lymphoblastic leukemia cell strain RS 4; 11 or a human primitive myeloid leukemia cell strain HL-60 has obvious killing effect and high selectivity, has the potential of being prepared into novel antitumor drugs and has better marketization prospect. |