http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110317281-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-0072 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 |
| filingDate | 2019-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110317281-B |
| titleOfInvention | Hyaluronic acid-g-folic acid amphiphilic polymer and application thereof |
| abstract | The invention discloses hyaluronic acid- g The main chain is hydrophilic hyaluronic acid, the side chain is hydrophobic folic acid, and the folic acid amphiphilic polymer can efficiently and stably load small-molecule anticancer drugs and prolong the blood circulation time of the drugs; the enrichment amount at the tumor part is high and reaches 12.0 percent ID/g, after reaching the tumor tissue, the dual-targeting nano-drug is tightly combined with the surface of the tumor cell and effectively enters the tumor cell through receptor-mediated endocytosis, and then the drug is quickly released in the tumor cell, thereby generating high-efficiency treatment effect. The polymer has good biocompatibility and degradability, and is convenient to be discharged out of a body; overcomes the defects of low drug delivery efficiency, small enrichment amount of tumor parts, low endocytosis efficiency of cells, slow release in cells and the like; the method is simple to prepare, the raw material sources are rich, and the obtained nano-drug has excellent freeze-drying redispersion performance and is beneficial to large-scale production and application. |
| priorityDate | 2019-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 73.