http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110317232-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F15-045 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F15-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 |
| filingDate | 2019-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110317232-B |
| titleOfInvention | Preparation method and application of amide multi-active compound |
| abstract | The invention discloses an amide multi-active compound and a preparation method and application thereof, the structural formula is as follows, the preparation method comprises the following steps: dissolving 2mmol of oxamide mononuclear copper ligand in 10-20ml of methanol, dissolving 2mmol of nickel salt in 5-10ml of methanol, adding the dissolved nickel salt into a methanol solution of the mononuclear copper ligand, reacting at 60 ℃ for 1 hour, then adding the methanol solution dissolved with 4mmol of 1, 10-phenanthroline ligand into a mixed solution of the ligands, refluxing at 60 ℃ for 5 hours, filtering, and slowly volatilizing the filtrate for 1 week to obtain a blue blocky crystal. Namely the bromine-containing oxamide ligand copper-nickel bimetallic coordination compound, wherein the nickel salt is as follows: nickel perchlorate, nickel chloride, nickel bromide, and the like. Compared with the platinum anticancer drugs commonly used at present, the compound of the invention has the characteristics of high anticancer activity, low cost, simple preparation method and the like. Meanwhile, the synthesized compound is found to have higher activity in the aspect of reducing blood sugar for the first time, and a new way is provided for developing medicines with related applications. |
| priorityDate | 2019-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.