http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110317218-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F1-005 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F1-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 |
| filingDate | 2019-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110317218-B |
| titleOfInvention | Preparation method and application of high-activity tetranuclear polymer |
| abstract | A preparation method and application of a high-activity tetranuclear polymer. The invention discloses a tetranuclear copper compound containing difluorooxamide ligand and a preparation method and application thereof, the structural formula is as follows, the preparation method comprises the following steps: dissolving 2mmol of oxamide mononuclear copper ligand in 10-20ml of methanol, dissolving 2mmol of copper salt in 5-10ml of methanol, adding the dissolved copper salt into a methanol solution of the mononuclear copper ligand, reacting for 1 hour at 60 ℃, then adding the methanol solution dissolved with 2mmol of 1, 10-phenanthroline ligand into a mixed solution of the ligand, refluxing for 5 hours at 60 ℃, filtering, and slowly volatilizing the filtrate for 1 week to obtain a blue blocky crystal. Namely the difluoro oxamide ligand-containing tetranuclear copper compound, wherein the copper salt is as follows: copper perchlorate, copper chloride, copper bromide, and the like. Compared with the platinum anticancer drugs commonly used at present, the compound of the invention has the characteristics of high anticancer activity, low cost, simple preparation method and the like. Meanwhile, the synthesized compound is found to have higher activity in the aspect of reducing blood sugar for the first time, and a new way is provided for developing medicines with related applications. |
| priorityDate | 2019-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.