http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110317132-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-41 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C57-30 |
| filingDate | 2019-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110317132-B |
| titleOfInvention | Preparation method of sodium phenylbutyrate |
| abstract | The invention discloses a preparation method of sodium phenylbutyrate. Adding the materials and anhydrous 2, 3-butanediol into a reaction container under inert atmosphere and uniformly mixing; the relevant materials include allylpalladium (II) chloride dimer, 2- (dicyclohexylphosphono) -1-phenyl-1H-pyrrole, N- (octaaminoquinoline) but-3-enamide, lithium acetate, bromobenzene, cyanoacetic acid and water; placing the reaction container in an oil bath at 125-135 ℃ and violently stirring for reaction for 12 hours, and purifying a reaction product through a silica gel column to obtain a compound with a guide group; adding the compound into an ethanol solvent containing sodium hydroxide, heating the mixture to 130-140 ℃, carrying out reflux reaction for 12 hours, and carrying out reduced pressure distillation on the reaction product to remove the solvent, extraction, water layer collection and water removal, thus obtaining the sodium phenylbutyrate preparation. The method has the characteristics of high reaction area selectivity and yield, mild reaction conditions and simple reaction and post-treatment purification processes. |
| priorityDate | 2019-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.