http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110308121-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2021-6432 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6428 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64 |
| filingDate | 2019-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110308121-B |
| titleOfInvention | Fluorescence detection method of antiepileptic drug-tiagabine hydrochloride (TGB) |
| abstract | The invention discloses a fluorescence detection method of an antiepileptic drug, namely tiagabine hydrochloride (TGB). Through studies on the interaction of the dye perylene diimide derivative (PDI), Human Serum Albumin (HSA) and tiagabine hydrochloride (TGB), we found that the fluorescence of PDI can be quenched by HSA, and our studies showed that PDI binds at site II of HSA while TGB can compete for binding at site II of HSA, so that PDI is competed from site II of HSA, thereby achieving fluorescence recovery. Based on the TGB, the invention provides a TGB fluorescence detection method, which uses PDI-HSA as a probe to realize fluorescence recovery under the action of TGB so as to detect TGB. The method has the advantages of original innovation, simple detection process, mild experimental conditions, high sensitivity, good selectivity, quick detection time, low detection limit and the like, and has good social value and application prospect. |
| priorityDate | 2019-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 80.