| abstract |
The invention relates to a spiro(3,3'-isopropylpyrrolidine oxidative indole) class of liver X receptor modulators and a preparation method and application thereof, and specifically proposes a compound, which is a compound represented by formula (I), Or a stereoisomer, geometric isomer, tautomer, nitrogen oxide, hydrate, solvate, metabolite, pharmaceutically acceptable salt or prodrug of the compound represented by formula (I). The compound has significant liver X receptor modulating activity, not only can be effectively used for the treatment or prevention of hyperlipidemia, fatty liver, obesity, diabetes, metabolic syndrome, or for targeting tumor energy metabolism, but also for glioblastoma Cell tumors and other cancers, atherosclerosis, dyslipidemia, metabolic syndrome, Parkinson's disease, Alzheimer's disease, multiple sclerosis, atopic dermatitis, rheumatoid arthritis and osteoporosis have significant curative effects and application prospects very broad. |