| abstract |
The invention discloses a nebivolol-based Smo inhibitor, a preparation method and application thereof. The structural formula of the Smo inhibitor is shown in formula (I); the invention also discloses its synthesis method and application. The invention uses nebivolol, a β-receptor blocker with inhibitory activity on Smo protein, as a lead compound, and optimizes and transforms it on the basis of it to obtain a Smo inhibitor with good inhibitory activity. |