| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5ed53d42b0f2da7049ebb4fb6cbeb905 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6949
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6923 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 |
| filingDate |
2019-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b16488ada54f51dd6cc3f03709eb2ca
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9bc72103fa6232677c5f7c975621f053
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be689a3558f43179bea8221e6b670302
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d0d1040f0bb1ba1079f014e4c86b139f |
| publicationDate |
2019-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-110302397-A |
| titleOfInvention |
pH-responsive graphene oxide nanosheet-coated mesoporous silica drug double-loaded composite nanoparticles and preparation method |
| abstract |
The invention relates to a pH-responsive graphene oxide nanosheet-coated mesoporous silica drug double-loaded composite nanoparticle and a preparation method thereof, comprising mesoporous silica nanoparticles and cinnamon loaded inside the mesoporous silica nanoparticles Aldehyde, graphene oxide nanosheets coated on the surface of mesoporous silica nanoparticles and doxorubicin loaded in the graphene oxide nanosheet structure. The preparation method is that aminated mesoporous silica nanoparticles and graphene oxide nanosheets are respectively loaded with cinnamaldehyde and doxorubicin through physical loading and π-π conjugation, and then obtained by electrostatic adsorption. The composite nanoparticle prepared by the invention has good biocompatibility, high drug loading capacity, less drug release in the neutral pH range, and can be quickly removed by the change of surface charge of graphene oxide nanosheets in the low pH environment of tumor cells. The surface covering layer realizes the responsive release of drugs, and ultimately improves the accumulation of drugs in cells, thereby enhancing the therapeutic effect of drugs while reducing their toxic and side effects. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114767871-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114010619-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113447553-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114010619-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111871393-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111871393-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110917143-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114767871-A |
| priorityDate |
2019-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |