http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110302209-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23V2002-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7125 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23L33-13 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7125 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23L33-13 |
| filingDate | 2019-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110302209-B |
| titleOfInvention | miR-451a antisense chain inhibitor and application thereof |
| abstract | The invention discloses a miR-451a antisense strand inhibitor and application thereof. According to the invention, a mouse alcoholic liver disease model is established, small molecular RNA deep sequencing is carried out on mouse liver tissues of a model group and a normal control group, differential high-expression miR-451a is obtained by analysis and screening, and qRT-PCR is used for verification. The miR-451a antisense chain inhibitor is chemically synthesized, and a mouse in-vivo experiment is carried out, and the result shows that the miR-451a antisense chain inhibitor can effectively reduce ALT and glutamic AST in the serum of a mouse with alcoholic fatty liver disease, and simultaneously obviously reduce fat accumulation in the liver, which indicates that the miR-451a antisense chain inhibitor can protect the liver function and relieve the alcoholic fatty liver disease. The miR-451a antisense strand inhibitor is expected to be developed into a novel micromolecular RNA medicament for treating alcoholic fatty liver disease. |
| priorityDate | 2019-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 302.