| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_22e589bd7da78e8d583b84d302f0c51e |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-513
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-513 |
| filingDate |
2019-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8f3518779acf4e8512c41aebc9331d7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23e37c65c82bf4fbe3fa59d36107c3a4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dcfbd8491b4f2401561e64e9945011e7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_815f72feedb32add1b2831ce89754b5a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c67750e1fb250314a9ca827882aff909
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3fc70cf9599a10343f71e22d6ea2e0ec |
| publicationDate |
2019-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-110295171-A |
| titleOfInvention |
Application of siRNA for Inhibiting NPC1 Gene Expression |
| abstract |
The invention discloses the application of siRNA for inhibiting the expression of NPC1 gene, belonging to the technical field of biomedicine. The siRNA for inhibiting the expression of NPC1 gene is at least one of the following two siRNAs: NPC1-siRNA-1, the nucleotides of the sense strand thereof The sequence is shown in SEQ ID NO.1, and the nucleotide sequence of its reaction chain is shown in SEQ ID NO.2; NPC1-siRNA-3, the nucleotide sequence of its sense chain is shown in SEQ ID NO.3, The nucleotide sequence of the reaction chain is shown in SEQ ID NO.4. The NPC1-siRNA-1 and NPC1-siRNA-3 designed by the present invention can well inhibit the expression of NPC1 gene in HCT-116 and HCT-8 cells; under the transfection of NPC1-siRNA-1 and NPC1-siRNA-3 , the drug resistance of tumor cells knocking down NPC1 to 5-FU is reduced; the NPC1-siRNA and 5-fluorouracil designed in the present invention can be used in combination to treat colorectal cancer. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112226434-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114703183-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112226434-A |
| priorityDate |
2019-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |