abstract |
The present invention relates to accyclic ASK1 inhibitors and applications thereof, in particular to compounds represented by general formula (I), pharmaceutically acceptable salts, esters or stereoisomers thereof. The present invention also relates to a preparation method of the compound, a pharmaceutical preparation and a pharmaceutical composition containing the compound. The compound of the present invention can effectively inhibit the amino acid phosphorylation of ASK1 and the activation of ASK1; therefore, it can treat and/or prevent ASK1-mediated diseases and related diseases. |