| abstract |
The invention aims to provide a method for reducing and deuterating unsaturated organic compounds containing carbon-carbon triple bonds and/or carbon-nitrogen triple bonds, which applies alkali metal mediated single electron transfer reaction to the reduction of the carbon-carbon triple bonds or the carbon-nitrogen triple bonds and can respectively convert alkyne and nitrile compounds into deuterated olefins (or alkanes) and alpha, alpha-dideuteroamine compounds in the presence of an alkali metal reagent, a deuterium donor reagent and an organic solvent. Halogen substituents in organic compounds are also reduced under the present reaction conditions to form the corresponding deuterated compounds. The novel reduction method of alkyne, nitrile and organic halide has the advantages of high yield and deuteration rate, safe and simple operation, easily obtained raw materials, short reaction time, no transition metal catalyst, expensive and flammable metal deuteride, flammable gas deuterium and the like in the preparation process, and no harmful by-product. |