http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110286118-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_653c418e41edbb4e1ce8bc5e53e70cec |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-763 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-74 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-74 |
| filingDate | 2019-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d4278b4dbaf6038c374332ddc2bc649 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4166cc4b28c58d0bab5155632f78170a |
| publicationDate | 2019-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110286118-A |
| titleOfInvention | A method for determining the mechanism of action of antibiotics using a bioluminescent reporter system |
| abstract | The invention discloses a method for determining the action mechanism of antibiotics by using a bioluminescent reporter system. It is to use the bioluminescent reporter system to prepare the lux reporter strain of Staphylococcus aureus, arrange the filter paper sheets of the solution containing antibiotics to be tested on the agarose double-layer plate containing the strain, cultivate and obtain the luminescent picture, and convert the luminescent picture into luminescent curve, extract the characteristics of the luminescence curve and compare the characteristic luminescence curves of known antibiotics for hierarchical clustering. If the luminescence curves of the detected antibiotics and the luminescence curves of antibiotics with known mechanisms of action are clustered together, it is determined that the mechanism of action of the antibiotic to be tested is similar to that of antibiotics with known mechanisms of action. Antibiotics with known mechanisms of action are the same. The method of the invention can realize the determination of the action mechanism of antibiotics, reduce the cost of identifying the action mechanism of antibiotics, increase the speed of identification of antibiotic action mechanisms, improve the ability of antibiotic screening, and has broad application prospects. |
| priorityDate | 2019-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 103.