http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110272351-A

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filingDate 2019-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb8f0479453abf1c03abe57dd960a630
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publicationDate 2019-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-110272351-A
titleOfInvention A kind of synthetic method of diclofenac
abstract The invention provides a synthesis method of diclofenac, which belongs to the technical field of drug synthesis; the specific reaction steps of the synthesis method of the invention are as follows: step 1): compound (a) is reacted in the presence of methanol/sodium methoxide to obtain compound (b); Step 2): compound (b) reacts with compound (c) in the presence of a base to obtain compound (d); step 3): compound (d) reacts with compound (e) in an organic solvent under the action of a catalyst, The compound (f) is obtained; the raw materials of the method are easy to obtain, the operation is simple, the yield is high, the cost is low, the three wastes are less, the safety is high, and it is suitable for industrial production.
priorityDate 2019-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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