| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_918b468caec358dab39547707dd26553 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-15043 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0004 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-91 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-867
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate |
2018-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7adc4ec42d505d8f69dc479bc7e831c3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43f48330faf812eb2cef56d957460865
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30e2be6f87ee3b6bb18dbf59aa74a266 |
| publicationDate |
2019-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-110257336-A |
| titleOfInvention |
An FTH knockdown human prostate cancer cell line |
| abstract |
The invention provides a lentivirus-infected human prostate cancer cell line (PC-3) to knock out endogenous genes, and successfully establish a stable screening cell line. Specifically, FTH-shRNA lentivirus was used to infect PC-3 cell line to silence FTH (ferritin heavy chain) expression, and FTH-knockdown PC-3 cell line was successfully established. The present invention confirms through research that FTH knockdown PC-3 cell line can stably silence FTH expression and passage. Compared with the negative control, the expression level of FTH protein in the PC-3 cell line after knockdown of FTH was significantly decreased, and the cell proliferation and migration abilities were significantly reduced. |
| priorityDate |
2018-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |