http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110256574-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-03 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 |
| filingDate | 2019-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110256574-B |
| titleOfInvention | Fusion polypeptide and its application in the preparation of antidepressant and neurodegenerative disease drugs |
| abstract | The disclosure belongs to the field of biotechnology, and in particular relates to a 9R‑eIF4A‑VI fusion polypeptide and its application in the preparation of antidepressant drugs. Public studies have confirmed that PDCD4 can bind to eukaryotic translation initiation factor (eIF4A) to inhibit the expression of brain-derived neurotrophic factor (BDNF), hinder the repair of damaged neuron cells and synaptic transmission, and aggravate the symptoms of depression. The present disclosure has screened and determined several domains that PDCD4 binds to eIF4A. By fusing the transmembrane sequence and a segment of eIF4A, a fusion polypeptide with interference effect is obtained. It is experimentally verified that the fusion polypeptide can effectively interfere with the combination of PDCD4 and eIF4A. , and has good transmembrane efficiency and stability, and can be used in the preparation of antidepressant drugs, which is of great significance. |
| priorityDate | 2019-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 172.