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filingDate 2019-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2021-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2021-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-110240712-B
titleOfInvention High-tensile, high-viscosity and self-healing double-network hydrogel for tissue adhesion and preparation method and application thereof
abstract The invention provides a design strategy of a novel adhesive hydrogel material, and a biocompatible hydrogel material with high stretching, self-repairing and high adhesion is obtained. Based on the design principle of a double-network structure, the material is characterized in that a first heavy covalent crosslinking network is formed by polymerizable polyethylene glycol-based macromolecules, and a second heavy non-covalent crosslinking network is formed by ultrahigh molecular weight hydrophilic macromolecules through entanglement. The mesh size of the first heavy network is required to be larger than the effective size of the molecules forming the second heavy network polymer, and the molecular weight of the polymer forming the second heavy network is required to be larger than the critical entanglement molecular weight, so that effective molecular entanglement is formed, and high stretchability, self-repairing property and high adhesiveness are endowed to the double-network hydrogel. The novel adhesive hydrogel can be quickly and repeatedly bonded with the surfaces of various materials, and can be quickly and repeatedly self-repaired after being damaged by external force. The material can be used as a cell culture carrier, a novel dressing without stitching and a wearable sensor.
priorityDate 2019-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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