| abstract |
The invention provides an aryl difluorobenzyl ether compound, a preparation method and application thereof, and particularly provides a compound shown as the following formula I, or pharmaceutically acceptable salt thereof, racemate, R-isomer, S-isomer, pharmaceutically acceptable salt or a mixture thereof. The compound shows better binding inhibition effect than the existing PD-1 inhibiting compound in a PD-1/PD-L1 competitive inhibition experiment, so that the compound can be used for preparing a pharmaceutical composition for treating diseases related to a PD-1/PD-L1 binding pathway. |