http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110237268-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0042 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0032 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0047 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0009 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0091 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6911 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2019-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2023-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2023-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110237268-B |
| titleOfInvention | A preparation method of dual-response liposome microbubble complex loaded with doxorubicin |
| abstract | The present invention relates to a preparation method of a dual-response liposome microbubble complex loaded with doxorubicin, which comprises the following steps: (1) reacting DSPE-PEG2000-NHS and cRGD to obtain DSPE-PEG2000-cRGD; (2) hydration reaction of DPPC, MSPC, DSPE‑PEG2000‑cRGD and DSPE‑PEG2000‑Biotin to obtain targeted thermosensitive liposome nanoparticles carrying cRGD peptide; (3) use targeted thermosensitive lipid The doxorubicin-carrying body nanoparticle is obtained to carry the cRGD peptide targeting doxorubicin temperature-sensitive liposome; (4) IR780 solution is added to the biotinylated lipid microbubble; (5) firstly take the IR780-loaded lipid microbubble Add avidin to the vesicles for incubation, and then add cRGD peptide targeting doxorubicin thermosensitive liposomes to obtain the double-responsive liposome-microbubble complex. The compound obtained by the method can not only reduce the loss of doxorubicin in the circulation, but also make the doxorubicin be concentrated in the center of the tumor. |
| priorityDate | 2019-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.