http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110237249-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f90c1df3857ee72900e0015c75caecd9 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55505 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5036 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-50 |
| filingDate | 2018-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83caba6a496498da704a30f2ff28cbb7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94cec07c7f481cdcd2d202f1f1371a38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3c6803c3200139b13d3cd293b07fdd9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08578b2d03d47e97e424b56557254db1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81cb832788a76a01466a1ad023ecd9e4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e22216b952e68aa94987c8601a907bf |
| publicationDate | 2019-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110237249-A |
| titleOfInvention | A novel aluminum adjuvant specifically targeting dendritic cells and its application in vaccine preparation |
| abstract | The invention constructs an antigen carrier system based on β-glucan particles (GPs) wrapping aluminum hydroxide colloid "GP-Al" structure to enhance the humoral immunity and cellular immune response of the body. The structures are of very uniform size, 2‑4 microns in diameter. The GP-Al particles can be loaded with antigenic proteins through a simple mixing procedure, thus avoiding any complex chemical or physical manipulation of the antigen. The system can greatly reduce antigen release and loss during delivery. In vitro and in vivo experiments demonstrated the excellent adjuvant properties of this GP-Al particle as a vaccine carrier. This system can target APCs with high specificity and strongly promote dendritic cell (DC) maturation and cytokine secretion. In vivo and in vitro experiments also showed that this system can enhance the proliferation and activation of antigen-specific CD8 T cells. In animal models, they can elicit strong Th1-biased immune responses and extremely high antibody titers, and have significant preventive and therapeutic effects on tumor growth, indicating that this vector system can stimulate both humoral and cellular immune responses. ability. We believe that this system can target APCs with high specificity and has broad application prospects in targeted drug delivery and expanding the application of aluminum adjuvants. |
| priorityDate | 2018-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 87.