http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110237037-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-438 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-438 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-107 |
| filingDate | 2019-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110237037-B |
| titleOfInvention | Unchristine solid lipid nanoparticles and preparation method thereof and freeze-dried powder preparation |
| abstract | The invention belongs to the technical field of nano-drugs, and in particular relates to a solid lipid nanoparticle of rhynchophylline and a preparation method thereof and a freeze-dried powder formulation. First, the rhynchophylline is dissolved in the melted oil phase, then the water phase is added and stirred to form a nanoemulsion, and then the nanoemulsion is placed in an ice-water bath to obtain; wherein: the oil phase is glycerol monostearate, Tween 80, A mixture of polyethylene glycol-15 hydroxystearate; the aqueous phase is purified water. The uncophylline solid lipid nanoparticles prepared by the invention are spherical or quasi-spherical, have no adhesion to each other, are evenly distributed, have good nanoparticle stability, have high encapsulation rate, and have high drug loading capacity; Dissolution, the 6-hour cumulative release percentage of urticine solid lipid nanoparticles by dialysis method is 50.45%; the uricine solid lipid nanoparticles lyophilized powder prepared by the present invention has smaller particle size after redissolving, appearance, color and luster. , and redispersibility are good. |
| priorityDate | 2019-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 53.