| abstract |
The invention discloses a small-molecule heterocyclic dimer for tumor treatment and its application. Described small molecule heterocyclic dimer has following structure: Experiments show that: the small molecule heterocyclic dimer of the present invention has a wide anti-tumor spectrum and strong anti-tumor activity, and is effective on human cervical cancer cells HeLa, human liver cancer cells Hep G2, human breast cancer cells MCF-7, and human pharyngeal squamous cell carcinoma cells FaDu. , The IC 50 of human non-small cell lung cancer cell A549 reaches μM level, which is much higher than that of the control drug ligustrazine, while the IC 50 of human breast cell MCF 10A is higher than that of tumor cells, reflecting the characteristics of high efficiency and low toxicity. The small molecule heterocyclic dimer of the present invention has potential application value in the development of antitumor drugs. |