http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110227065-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0033 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1271 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39558 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-02 |
| filingDate | 2019-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110227065-B |
| titleOfInvention | Folic acid targeting NaHCO3Liposome and application thereof in enhancing tumor immunotherapy effect |
| abstract | The invention discloses a folic acid targeting NaHCO-loaded carrier 3 Liposomes and their use in enhancing tumorsThe application in the aspect of tumor immunotherapy effect. The invention prepares NaHCO with liposome film as the shell 3 The formed nano-grade encapsulated NaHCO 3 Liposomes, said loaded NaHCO 3 The liposome can be adsorbed on tumor cells in a targeted manner, and phagocytosis of the liposome by the tumor cells is promoted, wherein the loaded NaHCO is 3 The liposome can increase tumor cell debris, promote the release of tumor antigen, and kill tumor cells. At the same time, the loaded NaHCO 3 The liposome combined with the PD-1 antibody has an inhibitory effect on tumors in vivo, can activate in vivo anti-tumor immunity, obviously increases CD8+ T cells in tumor tissues, can enhance the anti-tumor effect of the PD-1 antibody, and has good application prospects. |
| priorityDate | 2019-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.