| abstract |
A monoclonal antibody of anti-human PD-1, its preparation method and application. The anti-human PD-1 monoclonal antibody has good biological activity, can effectively combine with an extracellular region of a human PD-1 protein receptor, can effectively seal PD-1 protein at the protein level and the cell level, prevents the combination of the PD-1 protein and a ligand PD-L1, and effectively enhances the immune function. The monoclonal antibody can be applied to tumor immunotherapy and diagnosis and screening of PD-L1 positive tumor patients independently or in combination with other anti-tumor drugs, and has good prospects in preparation of drugs for treating tumors, resisting autoimmune diseases and the like. |