| abstract |
The present invention provides a compound and its preparation method and its application as a c-Met inhibitor. The compound has a structure shown in formula (X): wherein, A is hydrogen or B for or C is absent or is a benzene ring, and when C is a benzene ring, it forms a quinazoline group with the core structure; L 1 is -NH-CH 2 - or -O-; L 2 is absent or is -NH -; X is C or N; Y is O or S; R 1 is halogen or -NO 2 ; R 2 is Or ‑COR 5 ; R 3 is selected from halogen, alkyl and alkoxy; R 4 , R 5 are each independently C 3 ‑C 6 saturated or unsaturated cycloalkyl, aryl or heteroaryl; the ring Alkyl, aryl or heteroaryl is substituted or unsubstituted, and described substituent is selected from halogen, nitro, alkyl and substituted alkyl; Or, the isomer of formula (X) compound or its pharmaceutical acceptable salt. |