http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110204474-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-16 |
| filingDate | 2019-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110204474-B |
| titleOfInvention | Method for synthesizing tetra-substituted NH-pyrrole compound |
| abstract | The invention discloses a method for synthesizing a tetra-substituted NH-pyrrole compound, which comprises the following steps: in the presence of copper catalyst and alkali, unsaturated ketone compound shown in formula (1) and iminodiacetic acid ester compound shown in formula (2) undergo oxidation in solvent to form- [3+2]]Cycloaddition-aromatization series reaction to obtain the compound shown in formula (3) NH -pyrrole compounds of the formula: in the formulae (1) and (3), the substituent R 1 And R 2 Each independently selected from H, C1-C10 alkyl or aryl; in the formulae (2) and (3), the substituent R 3 Is C1-C10 alkyl, C1-C8 ester group, aryl or benzyl; substituent R 4 Is C1-C10 alkyl or aryl. The method has the advantages of cheap and easily obtained raw materials, few reaction steps, simple post-treatment and the like, can smoothly react under the air condition in the presence of a copper catalyst and alkali, does not need other additives and oxidants, and has high yield of target products and good applicability of reaction substrates. |
| priorityDate | 2019-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 135.