http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110198952-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12a9e9ce63eb0bbf3658453fb50a6d9b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-065 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-34 |
| filingDate | 2017-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c382f13fb6e0a79daaab3047d943c565 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8c8fdf37c685f606592472facd637848 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2de0905221565e24f09601771b04544c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f10dbbebfb8dc3bd1f7d73aa1b89c3fd |
| publicationDate | 2019-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110198952-A |
| titleOfInvention | Process for preparing highly concentrated liquid formulations containing biomolecules |
| abstract | The present invention discloses an improved multi-step method for the preparation of highly concentrated liquid formulations containing biomolecules, the method comprising the steps of: (a) a first ultrafiltration UF1; (b) a first diafiltration DF1; ( c) a second diafiltration DF2; and (d) a second ultrafiltration UF2; wherein an aqueous solution of one or more salts is used in step (b) as liquid medium B, and water or an aqueous solution of one or more salts is used as Liquid medium C is used in step (c), wherein the one or more salts used in step (b) are the same or different from the one or more salts used in step (c), and wherein the ionic strength of liquid medium B is higher than the ionic strength of liquid medium C. The method according to the invention allows the preparation of well-defined, highly concentrated formulations containing biomolecules, in particular proteins, for pharmaceutical or non-pharmaceutical use. Unwanted excipients of the starting liquid biomolecule formulation can be reduced to very low levels or levels below the detection limit under solution conditions. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111096456-A |
| priorityDate | 2016-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 873.