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classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-38
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-38
filingDate 2019-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2022-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2022-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-110194733-B
titleOfInvention A kind of preparation method of 3-difluoroalkyl-3-oxindolinone compound
abstract The invention relates to a preparation method of a 3-difluoroalkyl-3-oxindolinone compound. Under the protection of an inert gas, an α,α-difluoro-β-ketoacid compound and isatin are added to an organic solvent, Heating for decarboxylation addition reaction, that is, the preparation of 3-difluoroalkyl-3-oxindole compounds. Compared with the prior art, the raw materials used in the present invention are cheap, easy to obtain, mild in reaction conditions, can be carried out without using any catalyst, easy to operate in reaction, simple in post-treatment, and wide in scope of application. The new method of fluoroalkyl-3-oxindolinone compound has good application prospect.
priorityDate 2019-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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