http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110179992-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1ce61bf06f294f2f466c067ed41cc8ce |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5146 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P33-02 |
| filingDate | 2019-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc0a76508f1cab11f2a066fd4106518c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e9e63e30a6f93524363d02c6e372ef18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6644d8e9d6ebd732077a78f4c749299 |
| publicationDate | 2019-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110179992-A |
| titleOfInvention | A drug-polymer conjugate with high affinity to Cryptococcus neoformans and its preparation method and application |
| abstract | The invention relates to a drug-polymer conjugate with high affinity to Cryptococcus neoformans, a preparation method and application thereof, and belongs to the polymer field of pharmaceutical preparations. The drug-polymer conjugate in the present invention is the modification of amphotericin B on the surface of polylactic acid-glycolic acid copolymer-polyethylene glycol-N, hydroxysuccinimide, and its structure is shown in general formula I. The drug-polymer conjugate of the present invention has high affinity to Cryptococcus neoformans, and has good biocompatibility and biodegradability. After the drug-polymer conjugate is mixed with polylactic acid-co-glycolic acid copolymer-polyethylene glycol, the amphotericin B is encapsulated to form nanoparticles, which has a good effect on fungal infection, especially Cryptococcus neoformans infection in fungi. treatment effect. |
| priorityDate | 2019-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 60.