| abstract |
The present invention relates to the use of an immunogenic composition for infants comprising a multivalent Streptococcus pneumoniae vaccine in the preparation of a medicament for the treatment or prevention of diseases caused by Streptococcus pneumoniae infection, the multivalent Streptococcus pneumoniae vaccine comprising 12 species Capsular glycoconjugates from serotypes 1, 4, 5, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F, wherein the composition comprises serotype 22F glycoconjugates, wherein the disease is otitis media, meningitis, bacteremia, pneumonia, and/or conjunctivitis in human infants, and the 22F glycoconjugate is conjugated to CRM197 or PhtD, and the other serotypes are conjugated to a carrier protein independently selected from: TT, DT, CRM197, C fragment of TT, PhtD, PhtDE fusion, detoxified pneumolysin and D protein. |