http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110179971-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_adc3676e8ef9141c42f880beacc16376 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0011 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2019-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9800fd4ac2a631502d4bb6b493f01045 |
| publicationDate | 2019-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110179971-A |
| titleOfInvention | A kind of preparation method of tumor vaccine that removes regulatory T cells |
| abstract | The invention relates to the field of tumor vaccine production, and provides a preparation method of a tumor vaccine that removes regulatory T cells, which is used to solve the problem that the effect of the tumor vaccine is reduced by the regulatory T cells. The present invention provides a method for preparing a tumor vaccine that removes regulatory T cells, comprising: adding modified nano-tungsten oxide particles to the T lymphocyte population, wherein the weight ratio of the nano oxide particles to the T lymphocyte population is It is 1:100~500, irradiated under visible light for 3~10 minutes; the irradiated T lymphocyte population is magnetically sorted to obtain CD8+ T lymphocytes; the sensitized DC cells and the sorted CD8+ T lymphocytes are separated. The cells are mixed and cultured, and DC cells carrying tumor antigens present antigen information to CD8+ T lymphocytes and activate them to obtain specific tumor vaccines. After the T lymphocyte population is screened, the regulatory T cells are fully removed by adding nano-tungsten oxide particles and magnetic sorting, so as to improve the tumoricidal effect of the tumor vaccine. |
| priorityDate | 2019-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.