http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110179968-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-50 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 |
| filingDate | 2019-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110179968-B |
| titleOfInvention | Application of nucleolin in the preparation of drugs for improving glucose metabolism disorders |
| abstract | The invention provides the application of nucleolin in the preparation of drugs for improving glucose metabolism disorders, regulating the activity of glycogen synthase and regulating the phosphorylation level of glycogen synthase. By constructing a high-fat diet-induced glucose metabolism disorder model and a nucleolin overexpression mouse model, the present invention confirmed that nucleolin is a molecule related to glucose metabolism, and found that nucleolin can inhibit liver glycogen synthase phosphorylation, Increase the activity of glycogen synthase, thereby improving the glycogen synthesis ability of the liver tissue, enhancing the body's glucose tolerance and insulin sensitivity, participating in the regulation of the body's glucose homeostasis and treatment of glucose metabolism disorders. The role of insulin resistance provides a new target for the prevention and treatment of type 2 diabetes and prediabetes, and can be used to prepare drugs for early intervention of type 2 diabetes and delay the progress of the disease. |
| priorityDate | 2019-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1122.