http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110179789-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-365 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P33-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-365 |
| filingDate | 2019-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110179789-B |
| titleOfInvention | Application of parthenolide in preparation of toxoplasma gondii resistant medicine |
| abstract | The invention discloses an application of parthenolide in preparing anti-toxoplasma gondii drugs; the inventor proves that the parthenolide has obvious toxoplasmosis resistant effect through a large number of experiments, and is expected to become a new generation of medicine for treating toxoplasmosis. Parthenolide has a significant anti-toxoplasma effect: (1) cell experiment results show that 80mM of parthenolide can reduce the infection rate of cell populations to 22% compared with a blank control group; the proliferation rate of the polypide in a single cell can be reduced to 15 percent; (2) apoptosis experiments show that parthenolide can promote the apoptosis rate of toxoplasma cells; and the parthenolide has the advantage of low toxicity when being used as an anti-toxoplasma drug: the treatment experiment of parthenolide on the rat infected by the toxoplasma shows that the death rate of the rat is extremely low, and the protection rate is 100% when the parthenolide is 100 mg/Kg; the tissue is adopted for dissection, the shape and the size of each tissue of the rat are normal, and pathological section examination is carried out, so that no pathological change is seen. |
| priorityDate | 2019-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.