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filingDate 2018-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd3d50661a6cca834286ec4f5b7fb322
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publicationDate 2019-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-110177584-A
titleOfInvention Cryogenic gel 3D scaffold and method for producing the same
abstract Disclosed herein is a method for producing cryogel-based multi-interval 3D scaffolds. The method comprises the steps of: a) providing a first frozen polymer layer on a frozen support kept at a subzero temperature; b) providing a subsequent polymer layer to obtain a polymer layer by possibly adjusting the subzero temperature of the frozen support stacking; c) optionally incubating the final polymer structure at a subzero temperature; and d) subjecting the resulting cryogel to a temperature above 0°C, wherein each subsequent layer i) precedes the previous Deposited on the previous layer after the layer has frozen; ii) deposited on the previous layer before it is fully polymerized; and iii) deposited at a temperature higher than the freezing temperature of the previously deposited layer. Also disclosed are cryogel scaffolds obtained by the method.
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