| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1f732716d47d2ca82d4ded7a8860aac7 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-27
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-1114
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2503-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-1157
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-1121 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0688
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0697
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0639 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0784 |
| filingDate |
2017-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db9e2756a22bc111bb9d73bf7e1c008d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17941bd3440f64444abab230d05184ee
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_080b3dfd253a55f6e0bb066fe1b3bcce
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c6b20aac7286309990ef0b41de1b4137 |
| publicationDate |
2019-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-110168075-A |
| titleOfInvention |
Three-dimensional in vitro alveolar lung model, method for making the model, and use thereof for determining and/or predicting the sensitization effect of an inhalable substance |
| abstract |
The present invention relates to a three-dimensional in vitro alveolar lung model comprising basically the following four cell types: alveolar type II epithelial cells capable of secreting (pulmonary laying) surfactants, cells constituting the capillary lining that provides a permeability barrier Endothelial cells, dendritic cells (such as undifferentiated THP-1, linking innate and adaptive immunity), and macrophage-like cells are able to ingest foreign substances through phagocytosis and participate in defense mechanisms. The present invention also relates to methods of preparing such models, and their use in assessing the irritant potential or toxicity of inhalables such as particles or molecules to the alveolar barrier of the lung, and for determining and/or predicting the effects of inhalables such as particles or molecules on the alveolar barrier of the lung. Use of the sensitizing effect of the alveolar barrier of the lung. |
| priorityDate |
2016-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |