http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110156923-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-14 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F212-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F220-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K11-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F212-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F236-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F220-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F220-06 |
| filingDate | 2019-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110156923-B |
| titleOfInvention | Preparation method of carboxyl and polypeptide modified AIE polymer nanoparticles |
| abstract | A preparation method of AIE polymer nanoparticles modified by carboxyl and polypeptide comprises the following steps: 1) preparing an emulsifier aqueous solution; 2) dissolving AIE molecules, an austenite curing effect inhibitor and an oil-soluble initiator in a mixed solution of a carboxyl functional monomer and a hydrophobic monomer to obtain an oil phase solution; 3) adding the emulsifier aqueous solution into the oil phase solution, stirring and pre-emulsifying to obtain a coarse emulsion, and performing ultrasonic treatment to obtain a monomer fine emulsion; introducing nitrogen to remove oxygen to prepare carboxyl modified AIE polymer nano particle emulsion; 4) dissolving a carbodiimide condensing agent in an acidic pH buffer solution, and adding the carbodiimide condensing agent into the emulsion prepared in the step 3) for activation reaction; 5) dissolving omega-amino maleimide in an alkaline pH buffer; 6) adding the omega-amino maleimide solution into the emulsion prepared in the step 4) for reaction; 7) adding a polypeptide aqueous solution with a terminal containing a cysteine sequence unit into the emulsion prepared in the step 6), and reacting to prepare the carboxyl and polypeptide modified AIE polymer nano particles. |
| priorityDate | 2019-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 114.