| abstract |
The invention belongs to the synthetic field of Illudalane sesquiterpene, in particular to a total synthesis method of an Illudalane sesquiterpene reaction intermediate and a natural product, and the total synthesis method is used for synthesizing Illudalane Granulolactone, Echinolactone A, Radulactone and Riparol B among sesquiterpenes. The total synthesis method first synthesizes an ilutane-type sesquiterpene reaction intermediate, and then uses the reaction intermediate to undergo a double alkylation reaction to obtain the Echinolactone A; reduces the Echinolactone A to obtain the Radulactone; The ketone carbonyl of Echinolactone A is subjected to Clemmensen reduction reaction to obtain the Granulolactone; finally the Granulolactone is reduced to obtain the Riparol B. The total synthesis method is a "divergent" synthesis method, which synthesizes four ilutane-type sesquiterpene natural products, and has the advantages of fewer reaction steps, simple operation, and suitability for industrial production. |