http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110143957-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 |
| filingDate | 2019-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110143957-B |
| titleOfInvention | Preparation method of cefditoren pivoxil ring-opening product |
| abstract | The invention discloses a preparation method of cefditoren pivoxil ring-opening compound, which is characterized by comprising the following steps: adding cefditoren pivoxil and an organic solvent into a reaction vessel, dissolving under stirring, cooling to-20 to-5 ℃, slowly adding an alkaline substance, heating to 10 to 20 ℃ after adding, reacting, adding ethyl acetate and water, stirring and extracting, adjusting the pH value to 3-4 with acid, standing for layering, washing an organic layer with saturated saline, drying, filtering, concentrating under reduced pressure to dryness, and purifying by silica gel column chromatography to obtain the product. The content of the open-ring product of cefditoren pivoxil prepared by the preparation method provided by the invention can reach more than 95.0%, the yield can reach 70%, a theoretical basis is provided for safe use of medicines, effective data support is provided for the quality standard of cefditoren pivoxil, and effective guarantee is provided for clinical safe use of medicines. |
| priorityDate | 2019-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.