http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110143918-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-227 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-227 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 |
| filingDate | 2019-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110143918-B |
| titleOfInvention | 3, 4-dihydro-3- (2-hydroxybenzoyl) -2(1H) -quinolinone active skeleton, synthetic method and application |
| abstract | The invention discloses a 3, 4-dihydro-3- (2-hydroxybenzoyl) -2(1H) -quinolinone bioactive skeleton, a synthesis method and application thereof, wherein the structural formula of the 3, 4-dihydro-3- (2-hydroxybenzoyl) -2(1H) -quinolinone bioactive skeleton is shown in the specification In the formula, R1 is any one of methyl and ethyl; r2 is any one of hydrogen atom, methyl and halogen; r3 is any one of a hydrogen atom and a halogen. The synthesis method of the bioactive skeleton comprises the following steps: uniformly mixing an o-aminobenzaldehyde compound and a 4-hydroxycoumarin compound in a solvent according to a molar ratio of 1 (1-2), and reacting at 70-90 ℃ to obtain a 3, 4-dihydro-3- (2-hydroxybenzoyl) -2(1H) -quinolinone compound. The invention provides a method for efficiently synthesizing a 3, 4-dihydro-3- (2-hydroxybenzoyl) -2(1H) -quinolinone compound by one-step reaction in a green ethanol solvent without a catalyst, which realizes the synthesis of the 3, 4-dihydro-3- (2-hydroxybenzoyl) -2(1H) -quinolinone compound by the hydrogen migration reaction of a natural product molecule 4-hydroxycoumarin for the first time. |
| priorityDate | 2019-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 109.