| abstract |
The invention belongs to the technical field of medicine, and relates to a compound of formula I, its preparation method and use. , and is an integer; R 2 is selected from alkyl, phenyl, substituted phenyl, 5-6-membered aromatic heterocycle, m is taken from 0-5, and is an integer; R 3 is selected from phenyl, substituted phenyl, n Taken from 0 to 3 and is an integer, including the cis isomer, trans isomer or mixture of cis and trans isomers of the compound of formula I. The compounds of the present invention can strongly bind to α-synuclein aggregates, and can be used as imaging tracers in imaging techniques such as PET, SPECT, or in the preparation of imaging tracers, as well as including the imaging tracers. The composition of the invention has a very promising application to detect in particular Parkinson's disease or neurological disorders associated with α-synuclein misfolding and aggregation. |