| abstract |
The invention relates to the field of migration of antioxidants in pharmaceutical packaging, and specifically discloses a method for detecting 3,5-di-tert-butyl-4-hydroxyphenylpropionic acid and 2,4-di-tert-butylphenol in compound sodium chloride injection method, using liquid chromatography for detection. This method has investigated the content of 3,5-di-tert-butyl-4-hydroxyphenylpropionic acid and 2,4-di-tert-butylphenol in compound sodium chloride injection by using liquid chromatography, and its pretreatment adopts Direct filter injection, the process is simple and easy to operate; this method has excellent performance in terms of specificity, precision, accuracy, linearity, detection limit, quantification limit, etc., and can be used as a compound sodium chloride injection or similar matrix for detection3, General method for the content of 5-di-tert-butyl-4-hydroxyphenylpropanoic acid and 2,4-di-tert-butylphenol. |