| abstract |
The invention relates to a hybrid peptide with functions of regulating immunity, resisting oxidation, resisting inflammation and detoxifying, and a preparation method and application thereof. The hybrid peptide provided by the invention is named LTP, and is obtained by carrying out protein engineering computer design, hybridization, optimization and in-vitro and in-vivo double screening on antibacterial peptide LL-37 and thymopentin TP5, wherein the amino acid sequence is shown as SEQ ID NO. 1. The hybrid peptide LTP has high bidirectional immunoregulation activity, can enhance the immune function of an organism in a normal or immunosuppressive state, and protects the damage of immunosuppression to the organism; under the inflammatory state, the LTP can neutralize and digest endotoxin, inhibit the oxidation reaction and inflammatory reaction of organisms, relieve the damage of the inflammatory reaction to tissues, has the advantages of low cytotoxicity, high safety, simple preparation method, low cost and the like, can be used as an ideal immune, antioxidant and anti-inflammatory regulator or immune antioxidant detoxification peptide, and has good application potential and value. |