http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110128483-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F15-0093 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F15-00 |
| filingDate | 2019-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110128483-B |
| titleOfInvention | Carbonic anhydrase targeted tetravalent platinum complex and preparation method and application thereof |
| abstract | The invention discloses a carbonic anhydrase targeted tetravalent platinum complex and a preparation method and application thereof. The invention firstly provides carbonic anhydraseThe targeted tetravalent platinum complex has the targeted characteristic of carbonic anhydrase CAIX, can specifically identify tumor cells, effectively inhibit the activity of the CAIX, is nontoxic to normal cells, has enhanced toxicity under the hypoxic condition, and has remarkable anti-tumor activity; compared with bivalent platinum drugs, the complex has the characteristics of improving tumor selectivity, reducing liver injury, reducing kidney toxicity and having no toxic or side effect, can realize specific combination with an anti-tumor target point, and increases the sensitivity of the platinum drugs in a hypoxic environment. The invention also provides a preparation method of the complex, namely CAIxi and Pt (IV) -COOH x Mixing the obtained product in a DMF solution containing N, N-diisopropylethylamine for condensation reaction to obtain the complex. The preparation method is simple, has low cost, and has good application prospect and wide development space of the anti-tumor medicament. |
| priorityDate | 2019-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 66.