http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110128472-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2231-641 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2531-0241 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2231-643 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2531-822 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6561 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C29-145 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-249 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B53-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J31-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C29-145 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6561 |
| filingDate | 2018-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110128472-B |
| titleOfInvention | Synthesis and application of an oxaspirocyclic PNN-type ligand |
| abstract | The patent of the present invention belongs to the field of chiral synthesis, and specifically provides the synthesis of a new type of oxaspirocyclic PNN ligand. The ligand starts from oxaspirocyclic diphenol and undergoes trifluoromethanesulfonylation, palladium-catalyzed coupling of diarylphosphine oxide, trichlorosilylation reduction, palladium-catalyzed carbonyl esterification, hydrolysis, amination, and reductive amination and other steps to synthesize. The oxaspiro compound has central chirality. Therefore, there are left-handed oxaspiro PNN ligands and right-handed oxaspiro PNN ligands. The racemic oxaspiro PNN ligands can pass through the The spirocyclic diphenol is synthesized from the raw material. The PNN ligands of the present invention can be used as chiral ligands for asymmetric hydrogenation of ketones and lactones. Its complexes with iridium can yield enantioselectivities greater than 98% and 99% in the asymmetric hydrogenation of simple ketones and lactones, respectively. |
| priorityDate | 2018-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.