| abstract |
The invention belongs to the technical field of medicines, and relates to indoline compounds used as immunomodulators, stereoisomers and pharmaceutically acceptable salts thereof, a preparation method of the indoline compounds and the stereoisomers and pharmaceutically acceptable salts thereof, and a pharmaceutical composition containing the indoline compounds. The invention also relates to application of the compounds, stereoisomers and pharmaceutically acceptable salts thereof in preparing medicaments for treating diseases related to the PD-1/PD-L1 signal channel, such as cancers, infectious diseases and autoimmune diseases. The indoline compound and the stereoisomer and pharmaceutically acceptable salt thereof have the following structures, wherein substituents Cy, Q, X, Y and Z have the meanings given in the specification. The indoline compound and the stereoisomer, pharmaceutically acceptable salt or pharmaceutical composition thereof have obvious inhibition effect on PD-1/PD-L1 protein/protein interaction, and can be used for preparing medicines for treating diseases related to PD-1/PD-L1 protein/protein interaction, such as various diseases of cancer, virus infection and the like. |