http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110128385-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d40285e27f4ed83b8728b0d477404958 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-30 |
| filingDate | 2019-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c162bc50d87404b3fe82806ccc5c03f3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52ccb284bacd362d2a618d63e7aec190 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c549a7f39ea08d62cc6b026ab75e88e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2472d2b0e35e78f1a6082667e0f4fcb5 |
| publicationDate | 2019-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110128385-A |
| titleOfInvention | A kind of quercetin derivative chemically modified by dodecanoyl chloride and synthesis method thereof |
| abstract | The invention discloses a quercetin derivative chemically modified by dodecanoyl chloride and a synthesis method thereof, belonging to the field of pharmaceutical synthesis. Acidity regulator, under the condition of ice-water bath to room temperature, react for 8-10 hours, after the reaction, adjust the pH value to 6-7 with acid, add water, extract with ethyl acetate, separate liquids, and continue to use acetic acid for the water layer 2-3 times of ethyl ester extraction, the ethyl acetate layers were combined, a water absorbing agent was added, overnight, suction filtration, and the ethyl acetate was distilled off to obtain a crude product, which was purified by 200-300 mesh silica gel column chromatography, and the preparative liquid phase was purified again. Obtain high-purity quercetin derivatives. The quercetin derivative obtained by the invention chemically modifies the natural quercetin, and through the substitution reaction at the 4'-OH hydroxyl position, the water-solubility and fat-solubility of the quercetin derivative are improved, and the bioavailability is improved. This quercetin derivative can be used to treat diseases such as hypertension, myocardial ischemia and cancer. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110742863-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110742863-A |
| priorityDate | 2019-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 108.